' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
8.1
USERS' SCORE
Excellent
Based on 33 Reviews
9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Direct effect on back pain
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Read More
7
Vitamin D3 and low back pain
Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study.
Highlights vitamin D3's importance
We conducted a study to explore the connection between vitamin D3 levels and the impact of low back pain (LBP) on function and pain levels among a group of middle-aged Azeri individuals in North West Iran. Our case-control approach included 63 patients suffering from LBP and 55 healthy participants.
By analyzing blood samples, we found that the average serum concentration of 25-hydroxyvitamin D3 was notably lower in the LBP group compared to the healthy controls. This suggests that those with lower vitamin D levels are more likely to experience LBP.
Moreover, our analysis revealed a significant relationship between vitamin D3 levels and both pain intensity and disability. Specifically, we noted that lower vitamin D levels correlated with higher pain intensity as measured by a Visual Analogue Scale and greater functional disability assessed with the Modified Oswestry Questionnaire.
Overall, our findings highlight the potential role of vitamin D3 in managing back pain and suggest that addressing vitamin D deficiency could help improve outcomes for individuals suffering from LBP.
By analyzing blood samples, we found that the average serum concentration of 25-hydroxyvitamin D3 was notably lower in the LBP group compared to the healthy controls. This suggests that those with lower vitamin D levels are more likely to experience LBP.
Moreover, our analysis revealed a significant relationship between vitamin D3 levels and both pain intensity and disability. Specifically, we noted that lower vitamin D levels correlated with higher pain intensity as measured by a Visual Analogue Scale and greater functional disability assessed with the Modified Oswestry Questionnaire.
Overall, our findings highlight the potential role of vitamin D3 in managing back pain and suggest that addressing vitamin D deficiency could help improve outcomes for individuals suffering from LBP.
Read More
7
Vitamin D3 may reduce back pain
Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults.
Highly relevant to vitamin D3 effects
We explored the potential benefits of vitamin D3 supplementation for alleviating back pain in overweight or obese adults who were also vitamin D deficient. In a controlled study, 65 participants with a body mass index (BMI) of 25 or higher and low vitamin D levels received either a high dose of vitamin D3 or a placebo for 16 weeks.
After the treatment, we found that while vitamin D levels significantly increased in those taking the supplement, there were no overall significant differences in back pain intensity or disability scores between the vitamin D group and the placebo group.
However, it was noteworthy that among participants whose vitamin D levels were particularly low—under 30 nmol/L—those taking vitamin D did experience a meaningful reduction in back pain disability compared to those receiving placebo. This indicates that addressing severe vitamin D deficiency might not only support bone health but also improve the quality of life for those suffering from back pain—especially in overweight individuals.
These insights invite consideration for regular vitamin D testing in this demographic, offering a potential pathway to managing back pain more effectively.
After the treatment, we found that while vitamin D levels significantly increased in those taking the supplement, there were no overall significant differences in back pain intensity or disability scores between the vitamin D group and the placebo group.
However, it was noteworthy that among participants whose vitamin D levels were particularly low—under 30 nmol/L—those taking vitamin D did experience a meaningful reduction in back pain disability compared to those receiving placebo. This indicates that addressing severe vitamin D deficiency might not only support bone health but also improve the quality of life for those suffering from back pain—especially in overweight individuals.
These insights invite consideration for regular vitamin D testing in this demographic, offering a potential pathway to managing back pain more effectively.
Read More
Most Useful Reviews
9.5
Eliminated back pain
Before taking this Vitamin D3, I had crippling pain in my joints, bones and muscles. After just one week, my deep aching pain has vanished. I now feel like an 18-year-old, with more energy than I’ve had in years. At 48, I previously felt like I was 88. This truly helps.
Read More
9.5
Improved back pain
Чудово! I’ve been using this vitamin for over a month. It has helped me recover from chronic back pain, improved my mood, and restored my self-confidence.
Read More
9.5
Relieved back pain
My Miracle is Here! Before taking this Vitamin D3, I had debilitating pain in all my joints, bones and muscles. After just a week, I feel young again—my constant aching pain has disappeared! I now have energy like never before at 48, having felt like I was 88 before.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
8.1
9.5
Pregnancy osteoporosis therapy outcomes
Successful neridronate therapy in pregnancy-associated osteoporosis.
Combined treatment limits isolation
We observed a rare condition known as pregnancy-associated osteoporosis, which affected a 38-year-old woman after she gave birth. Just a month postpartum, she experienced sudden back pain due to four vertebral fractures, and her bone density was notably low, especially in the spine.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
Read More
9.5
PLO treatment and vitamin D3
Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature.
Vitamin D3's role is unclear
We explored the impact of various treatments, including vitamin D3, on severe back pain caused by pregnancy-related osteoporosis (PLO). In a significant case study, a 23-year-old woman experiencing debilitating back pain was treated after her first childbirth. By monitoring her bone mineral density, we noted low T- and Z-scores in her lumbar spine.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
Read More
9
Denosumab improves back pain outcomes
Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures.
Difficulty isolating vitamin D3 impact
We explored the effectiveness of denosumab on alleviating back pain and enhancing quality of life in post-menopausal women suffering from vertebral fractures. This study, involving 140 women aged around 70, assessed participants who received denosumab alongside calcium and vitamin D3 for a year.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
Read More
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Direct effect on back pain
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Read More
9
Vitamin D aids musculoskeletal pain relief
A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain.
General relevance to musculoskeletal pain
We investigated the impact of adding 4000 IU of vitamin D3 on managing musculoskeletal pain, which includes back pain. In our study, we designed a randomized, double-blind, placebo-controlled trial involving 80 patients over three months. Each participant received either the vitamin D supplement or a placebo while their pain levels were monitored.
Our findings revealed that the group taking vitamin D experienced greater improvements in their pain levels, as measured by the Visual Analogue Scale (VAS). Notably, they reported a significant decline in pain compared to those receiving the placebo. Additionally, the need for rescue analgesics was markedly reduced among patients receiving vitamin D.
We also observed interesting changes in inflammatory markers. Specifically, levels of tumor necrosis factor alpha (TNFα) and prostaglandin E2 (PGE2) dropped significantly in the vitamin D group, indicating less inflammation compared to the placebo group, which actually saw increases in these markers.
In conclusion, incorporating a high dose of vitamin D may provide relief for those suffering from musculoskeletal pain, potentially through its effects on inflammation and pain perception.
Our findings revealed that the group taking vitamin D experienced greater improvements in their pain levels, as measured by the Visual Analogue Scale (VAS). Notably, they reported a significant decline in pain compared to those receiving the placebo. Additionally, the need for rescue analgesics was markedly reduced among patients receiving vitamin D.
We also observed interesting changes in inflammatory markers. Specifically, levels of tumor necrosis factor alpha (TNFα) and prostaglandin E2 (PGE2) dropped significantly in the vitamin D group, indicating less inflammation compared to the placebo group, which actually saw increases in these markers.
In conclusion, incorporating a high dose of vitamin D may provide relief for those suffering from musculoskeletal pain, potentially through its effects on inflammation and pain perception.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 33 Reviews
9
9.5
Eliminated back pain
Before taking this Vitamin D3, I had crippling pain in my joints, bones and muscles. After just one week, my deep aching pain has vanished. I now feel like an 18-year-old, with more energy than I’ve had in years. At 48, I previously felt like I was 88. This truly helps.
9.5
Improved back pain
Чудово! I’ve been using this vitamin for over a month. It has helped me recover from chronic back pain, improved my mood, and restored my self-confidence.
9.5
Boosted recovery from back pain
I had a terrible cold before starting this vitamin, but within a few days of taking it, I felt tremendous! My immune system is functioning well. Plus, I don’t need to take as many pills daily as with other supplements.
9.5
Normalised back pain
During my pregnancy, my vitamin D levels dropped significantly, but this supplement restored them quickly. I am delighted with the results, and the effects last a long time.
9.5
Relieved back pain
My Miracle is Here! Before taking this Vitamin D3, I had debilitating pain in all my joints, bones and muscles. After just a week, I feel young again—my constant aching pain has disappeared! I now have energy like never before at 48, having felt like I was 88 before.
